Mouthrinse combining chlorhexidine digluconate and cetylpyridinium chloride: demonstration of the in vitro benefit considering antimicrobial and plaque control properties. - ROS - 2012 - Tome 41 - N°3

The present study demonstrates the in vitro interest of combining two cationic antiseptic agents : chlorhexidine digluconate and cetylpyridiniumchloride in a mouthrinse formulation (EludrilCARE®). In a first step the antimicrobial activity of the products alone or associated was checked according to European Standard NF EN 1040. When combined, the two products are more efficient than tested alone, underlying a positive interaction. This effect was controlled on the main bacterial species implicated in periodontal diseases. In a last step, the plaque control efficiency of themouthrinse was demonstrated using the "Guggenheim" model, on young and mature biofilms with significant reduction of the viable bacterial populations when compared to the control.